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The mouse was generated by CRISPRCas9 technology to remove exons 24, resulting in frameshift and protein reading frame premature termination, the genotyping primers are: forward primer, 5-TGCTGCCGTCATTTTCTGCCTCAT-3

PMID: 19016404

Polyester modification of the mammalian TRPM8 channel protein: implications for structure and function

On the other hand, Vitamin C is important in limiting free radical damage in the aqueous phase of the cell, and cellular vitamin C status may be linked to the mechanisms involved in quenching cellular reactive oxygen species

Brenner's team discovered that the antioxidant GSH produced by T cells serves not only as a garbage collector to dispose of reactive oxygen species (ROS) and free radicals, but also as a key switch for energy metabolism that controls the immune response, and is thus of high relevance to various diseases